NHL中HCV感染与P53表达的相关性

The relation and signification of HCV infection and P53,bcl-6 expression in malignant non-Hodgki n’s lymphomas

目的探讨非霍奇金淋巴瘤 (NHL)中丙型肝炎病毒 (HCV)的感染与P5 3表达的相关性及其意义。方法应用免疫组织化学S P法对 133例NHL和 2 5例良性淋巴组织病变 (BLPC)进行P5 3及HCVTORDJI 2 2蛋白的检测 ,对其中 5 8例NHL和全部BLPC进行HCVRNA的原位RT PCR检测。结果HCV感染阳性共 17例 (TORDJI 2 2阳性 9例 ,HCVRNA阳性 11例 ,双阳性 4例 ) ,感染阳性率为 12 8% (17/ 133) ,BLPC中HCV感染阴性 ,两组比较差异有显著性 (P <0 0 5 )。NHL中P5 3阳性 71例 (5 3 4 % ) ,BLPC中P5 3均为阴性。 17例HCV阳性NHL中P5 3阳性 13例 (P <0 0 5 )。结论 (1)HCV感染与NHL之间有相关性 ;(2 )HCV可能通过调控P5 3的表达而参与NHL的发生。

Objective To investigate the pertinence and signification of the Hepatitis C virus(HCV) infection and P53 protein expression in malignant non-Hodgkin’s lymphomas(NHL).Methods The P53 and HCV TORDJI-22 protein were detected in 133 cases of NHLs and 25 cases of benign lymphoid tissue pathological change(BLPC) by immunohistochemistry staining and the HCV RNA was detected in 58 cases of NHLs and all of the BLPCs.Results HCV infection was found in 17 cases of NHL,while in none of BLPCs (P<0.05);The P53 protein expression was positive in 71 cases of NHL(53.45%),but negative in all of BLPC.P53 was positive in 13 of 17 HCV positive NHLs (P<0.05).Conclusion There is certain pertinence between the infection of HCV and NHL;HCV may involved in the role of P53 contributing to the occurrence of NHL.