电针治疗对老年性痴呆大鼠血清β淀粉样蛋白及生长因子水平的影响

Effects of Electropuncture Therapy on Levels of β-AP and TGF-α in Rats of AD Model

目的:观察电针对老年性痴呆(AD)模型大鼠β-淀粉样蛋白及转化生长因子(TGF-α)的影响,揭示针灸治疗的作用机理和针灸治疗AD的免疫基础。方法:建立AD大鼠模型,随机分为电针组、喜得镇组、模型自然恢复组、假手术组,观察血清β-AP和TGF-α水平。结果:电针组和喜得镇组大鼠血清β-AP水平明显下降(P<0.05),但仍明显高于假手术组。结论:电针能降低AD模型大鼠血清中β淀粉样蛋白及TGF-α。

Objective:To observe the effect of treating AD with electropuncture and study its mechanism. To observeβ-AP and TGF-α level in the blood of AD model after treatment course and investigate the mechanism of treating AD with electropuncture. Methods:All animals were randomly divided into four groups:group A (electropuncture group)、group B (Hydergine group)、group C (model group)、group D (pseudo injuried group), and models of AD were established by immobilization among A、B、C group. Group A was treated by electropuncture, group B was treated by Hydergine. Results:β-AP and TGF-α in the blood of group A and B was decreased significantly compared with that of group C and D (P<0.05) after treatment. Conclusion:Electropuncture had definitely increasing intellect effect to AD model, which could decrease the high level of β-AP and TGF-α in the blood of AD models and so as to achieve the therapeutic effect.