卵巢无性细胞瘤27例临床分析

Ginical analysis of 27 cases of dysgerminoma of ovary

目的 探讨卵巢无性细胞瘤的合理治疗方案。方法 回顾性分析了10年间经我院治疗的卵巢无性细胞瘤27例的临床资料。按治疗特点不同分组,A组手术范围大,基本不考虑保留生育机能,术后以放疗为主;B组多行保守性手术,以患侧附件切除为主,术后辅以规范的化疗。比较两组5年生存率和患者月经及生育情况。结果 A组5年生存率为58.8％(10/17),B组5年生存率为90.0％(9/10),两组相比差异有显著性(P<0.05)。B组中6例现月经正常,3例已生育。结论卵巢无性细胞瘤应采取以手术为主辅以化疗的综合治疗,既可最大限度保留生育功能,又能提高5年生存率。在进行保留生育功能手术和处理时应注意手术的全面性、正规化疗的重要性和随访的长期性。

Objective To study the reasonable treatment of dysgerminoma of ovary. Methods 27 cases of dysgerminoma of ovary were retrospectively analysed. All of the cases were devided into two groups according to their treatment methods. Cases in group A were operated without considering fertility and mainly given radiotherapy after operation. Cases in group B were mainly given conservative operations and standardized chemotherapy after operation. The 5-year survival rates and the patients' menstruation and fertility states in the 2 groups were compared. Results Five-year survival rates of group A and B were 58.8% (10/17) and 90.0% (9/10) respectively, with significant difference(P < 0.05) . Six cases in group B had normal menstruation and 3 of them gave childbirth. Conclusion Operation combined with chemotherapy for treatment of dysgerminoma of ovary increases patients' survival rate and reserves their fertility. Attention should be payed to the completeness of operation, importance of standardized chemotherapy and insistance of follow-up study.