摘要
采用酯化反应,将烟酰氯和β-谷甾醇合成了β-谷甾醇烟酸酯,并用红外光谱和质谱对其进行了分析。结果表明,酯化反应的最优工艺条件为mol(β-甾醇):mol(烟酰氯):mol(吡啶)= 1:3:5;反应温度91℃;反应时间6 h;用95%的乙醇进行重结晶,产率可达到75%以上;红外光谱和质谱分析表明合成产物为β-谷甾醇烟酸酯。
An esterification process is adopted for synthesis ofβ-sitosterol nicotinate with trinicotinate andβ-sitosterol. The product was then determined with infrared spectrum and mass spectrum and the result showed that the optimal synthetic conditions were as follows: molar ratio ofβ-sitosterol/trinicoti-nate/pyridine should be 1:3:5, with reaction temperature and reaction time being 91℃and 6 h respectively. Yield may reach up to over 75% in conditions mentioned above using ethanol (95% concentration) as recyrstallization agent. Analysis with infrared and mass spectrums proves that the synthesized product isβ-sitosterol nicotinate.
出处
《武汉生物工程学院学报》
2007年第3期128-132,共5页
Journal of Wuhan Bioengineering Institute
基金
湖北省教育厅基金项目(D200514004)
关键词
β-谷甾醇烟酸酯
烟酰氯
红外光谱
质谱
β-sitosterol nicotinate
trinicotinate
infrared spectrum
mass spectrum
