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DMT 1在THP-1氧化LDL过程中对基因表达的影响

Effect of DMT 1 on Gene Expression in the Process That THP-1 in Oxidizing LDL
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摘要 采用RT-PCR法和Western blot法对二价拿属转运蛋白1(divalent metal transporter 1, DMT 1)在人单核细胞系THP-1氧化低密度脂蛋白(low density lipoprotein,LDL)的过程中所起到的作用进行了验证。结果表明,DMT 1参与了THP-1氧化LDL的过程,且DMT 1的表达水平显著升高,为临床心血管疾病的抗氧化治疗提供了新的思路。 RT-PCR and Western blot were adopted to verify the action performed by divalent metal transporter 1 (DMT 1) in the process of oxidation mediate human THP-1 monocyte and low density Iipopro-tein (LDL). Result showed that DMT 1 was involved in the process of the above-mentioned oxidation, in which the mRNA express level rose significantly. The result also suggested a new train of thought for clinical anti-oxidized treatment upon cardiovascular disease.
作者 龚杰 武军驻
机构地区 武汉大学基础医学院
出处 《武汉生物工程学院学报》 2007年第3期141-143,共3页 Journal of Wuhan Bioengineering Institute
基金 教育部留学回国人员科研启动基金项目(2005-546)
关键词 二价金属离子转运蛋白1 低密度脂蛋白 动脉粥样硬化 divalent metal transporter 1 low density lipoprotein atherosclerosis
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献12

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二级参考文献9

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武汉生物工程学院学报
2007年 第3期

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