相转移催化合成N-取代酞酰亚胺衍生物

The Synthesis of N-substituted Derivatives of Phthalimides under PTC

研究了相转移催化条件下,酞酰亚胺与α＿位有吸电子基团的含活泼双键化合物的Michael加成反应,应用这一有效方法合成了N＿取代酞酰亚胺构建单元,例如β＿酞酰亚胺基丙酸丁酯、β＿(4＿硝基酞酰亚胺基)丙腈等8个化合物。并用IR、EA和1HNMR等方法对产物结构进行表征。

Michael addition of phthalimides to (C)(C) double bond compounds having electron withdrawing group in the α-position under PTC condition is described. Eight compounds,such as N-phthalyl-β-alanine butyl ester and β-(4-nitrophthalimido),in which N-substituted derivatives of phthalimides serving as building blocks, were synthesized by this convenient method. Their structures were identified by means of IR, EA, and ()~1H NMR.