TTF-1在肺癌诊断分型中的应用

Application of TTF-1 on Classification of Lung Carcinoma

目的明确甲状腺转录因子-1(TTF-1)在肺鳞癌中的表达情况,探讨TTF-1在肺癌分型中的诊断价值。方法应用免疫组织化学S-P法染色对140例肺活检组织中TTF-1蛋白进行检测,分析临床资料并回顾文献。结果本项研究中,TTF-1在27例肺腺癌中均阳性表达,在54例肺鳞状细胞癌中则无一例表达,它们之间差异有统计学意义(P <0. 01);另外肺小细胞癌TTF-1的阳性率高达95%。结论 TTF-1在肺鳞癌中表达缺失,在肺腺癌的表达率高。其准确判读有助于作出正确的肺癌组织学分型。

Objective To identify the expression of thyroid transcription factor 1(TTF-1)in the squamous cell carcinoma of lung,and to explore its diagnostic value in classification of lung cancer.Methods TTF-1 from 140 biopsy specimens of lung were detected with S-P staining of immunohistochemistry,and their clinical data were analyzed and relevant literatures were reviewed.Results In this study,27 specimens of lung adenocarcinomas have showed positivity for TTF-1,and TTF-1 was not expressed in 54 specimens of squamous cell carcinoma of lung,the difference was statistically significant(P<0.01);in addition,the positive rate of TTF-1 was up to 95%in small cell lung carcinoma.Conclusion TTF-1 is not expressed in the squamous cell carcinoma of lung and has high expression in the lung adenocarcinomas.The correct determination of TTF-1 contributes to correct classification of lung cancer.