VEGF、ER、PR及AR在颈鼓室副神经节瘤的表达

The Expressions of VEGF,ER, PR or AR in Jugulotympanic Paraganglioma

目的观察血管内皮生长因子(vascular endothelial growth factor,VEGF)及雌激素受体(estrogen receptor,ER)、孕激受体(progestogen receptor,PR)、雄激素受体(androgen receptor,AR)在颈鼓室副神经节瘤的表达,分析其与肿瘤生物学行为的关系。方法回顾性分析17例颈鼓室副神经节瘤的临床资料,对其存档的手术标本行Envision法免疫组织化学检查,并运用SPSS 10.0 for Windows对资料进行Spearman等级相关分析。结果在17例标本中,11例表达VEGF,且表达强度与Fisch分级相关,r=0.529,P<0.05;无1例表达ER、PR及AR。结论 VEGF可能对颈鼓室副神经节瘤的生长有促进作用;颈鼓室副神经节瘤的性别偏向似乎与性激素异常无关。

Purpose To observe the expressions of vascular endothelial growth factor (VEGF) , estrogen receptor (ER) ,progestogen receptor (PR) or androgen receptor (AR) in jugulotympanic paraganglioma. Methods Clinical materials from 17 cases of jugulotympanic paraganglioma were analyzed retrospectively. The archival specimens were examined immunohistochemically. Spearman rank correlation was executed using SPSS 10.0 for Windows. Results 11 archival specimens (11/17)expressed VEGF. None of them expressed ER, PR or AR. VEGF expression levels were correlated with Fisch classifications (r = 0.529, P < 0.05). Conclusion VEGF may accelerate the growth of jugulotympanic paraganglioma. It seems that sex predilection of jugulotympanic paraganglioma has nothing to do with sex hormones.