眼睑眼眶恶性淋巴瘤的临床病理分析

A Clinicopathological Study of eyelid/conjunctiva and orbital Lymphomas

目的总结眼部恶性淋巴瘤的临床病理学特征,探讨其可能的致病机制。方法回顾分析3年46例眼部恶性淋巴瘤的临床病理资料。结果眼睑、结膜恶性淋巴瘤14例,占同期眼睑、结膜恶性肿瘤的11.2%;眼眶恶性淋巴瘤32例,占同期眼眶实体性肿瘤的11.3%。均大大高于国内外文献报道(1～3%)。免疫组织化学染色33例(71.7%),均为非霍奇金淋巴瘤,其中32例为低度恶性B细胞黏膜相关性淋巴瘤,且λ表达者高达92.3%,1例为T细胞性淋巴瘤。结论眼部淋巴瘤多为低度恶性B细胞黏膜相关性淋巴瘤,免疫组织化学检查有助于诊断,其发病率具有相当大的地域性差异。

Purpose To summarize the clinicopathological features of a large number of ocular lymphomas and thereby discuss the possible mechanisms.Methods A retrospective study of 46 cases was made. Results Eyelid/ conjunctival lymphomas accouted for 11.2% of malignant tumors on eyelid/conjunctiva and orbital lymphomas accounted for 11.3% of orbital tumors. Both ratios are much higher than that in other reports at home and abroad. Immunohistochemistry analysis was made in 33 cases (71.7%) . According to REAL standard, all 33 cases were non-Hodgkin's lymphomas,among which 32 cases were low grade mucosa associated lymphoid tissue(MALT)-type lymphomas. Conclusion The main subtype in ocular lymphoma is MALT-type lymphoma.Immunohistochemistry is helpful in the diagnosis.The high prevalence in eastern China means geographical variance.