内皮素-1在炎症性肠病发病中作用的研究进展

Progress in Study on Endothelin-1 in Pathogenesis of Inflammatory Bowel Disease

炎症性肠病(IBD)是一种病因尚未完全明确的慢性非特异性肠道炎性疾病,包括克罗恩病(CD)和溃疡性结肠炎(UC)。内皮素-1(ET-1)是一种由21个氨基酸残基组成的活性多肽,具有较强的收缩力,可通过活化血管平滑肌的电位依赖性钙离子通道发挥收缩血管作用。研究显示ET-1在IBD的发生、发展中发挥重要作用。本文就ET-1在IBD发病中作用的研究进展作一综述。

Inflammatory bowel disease( IBD) is a kind of chronic and non-specific inflammatory disease comprising Crohn’s disease( CD) and ulcerative colitis( UC),the etiology has not yet been clarified. Endothelin-1( ET-1) is an active polypeptide composed of 21 amino acid residues,which can constrict blood vessels by activating voltage-dependent Ca2 +channels in vascular smooth muscle cells. Studies have shown that ET-1 plays an important role in the pathogenesis of IBD. This article reviewed the progress in study on ET-1 in the pathogenesis of IBD.