摘要
结直肠癌是常见的恶性肿瘤,侵袭转移是导致患者死亡的主要原因。上皮-间质转化(EMT)是上皮细胞转变为间质表型的过程,参与包括结直肠癌在内多种肿瘤的发生、发展、侵袭和转移,并与肿瘤化疗耐药密切相关。EMT的发生涉及多条信号通路,但其机制尚未完全阐明。本文就EMT机制及其在结直肠癌中的研究进展作一综述。
Colorectal cancer is a common malignant tumor,and invasion and metastasis are the major causes of death. Epithelial-mesenchymal transition( EMT) occurs along with transition from epithelial phenotype to mesenchymal phenotype. EMT is involved in the genesis,development,invasion and metastasis of various tumors including colorectal cancer. EMT is closely associated with chemotherapy resistance of tumors. Various signaling pathways are involved in the pathogenesis of EMT and its mechanism is not fully clear. This article reviewed the molecular mechanism and role of EMT in colorectal cancer.
出处
《胃肠病学》
2016年第5期307-310,共4页
Chinese Journal of Gastroenterology
关键词
上皮-间质转化
结直肠肿瘤
分子机制
信号通路
抗药性
肿瘤
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Molecular Mechanism
Signal Pathway
Drug Resistance
Neoplasm
