诱导化疗配合放疗治疗晚期鼻咽癌近期效果分析

The latest curative effect of radiotherapy combined with inducing chemotherapy on advanced nasopharyngeal carcinoma

目的 观察诱导化疗配合放疗治疗晚期鼻咽癌的近期疗效及急性不良反应。方法 将68例晚期鼻咽癌患者随机分为放、化疗组(观察组)和单纯放疗组(对照组),两组放疗方法相同,观察组于放疗前给予HCPT、DDP、5-Fu化疗。比较两组近期疗效及急性不良反应。结果 放疗结束后3个月,观察组鼻咽部肿瘤完全退缩率及颈淋巴结完全退缩率高于对照组,但差异无显著性。急性不良反应中,观察组的恶心、呕吐及白细胞下降均较对照组明显增多(P<0.05);皮肤、粘膜反应增加不明显。结论 HCPT、DDP、5-Fu诱导化疗不能提高晚期鼻咽癌的近期局部控制率,急性不良反应较单纯放疗明显。

Objective To observe the latest curative effect and acute side - effect of radiotherapy combined with inducing chemotherapy on treating nasopharygeal carcinomas. Methods 68 cases of advanced nasopharyngeal carcinomas were divided randomly into an observation group (radiotherapy combined with chemotherapy) and a control group (radiotherapy alone), both of which were given the same radical radiotherapies, and the former group received additional HCPT, DDP and 5 - FU before radiotherapy. The latest curative effect and acute side - effect of treatment were compared between these two groups. Results 3 months after radiotherapy, the overall shrinking rate of nasopharyngeal tumor and jugular lymphaden in the observation group is higher than that in the control group, though there were no significant difference. The occurring of nausea, vomit and leucocyte declining in the observation group are more than those in the control group, they were significant differences. The occurring of derma and membrane reaction in the observation group was not so obvious. Conclusion HCPT, DDP, 5 - FU as inducing chemotherapy can not improve the latest local control rate of advanced nasopharyngeal carcinomas, with distinct side - effect than radiothery alone.