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Liver transplantation in a patient with primary antiphospholipid syndrome and Budd-Chiari syndrome

Liver transplantation in a patient with primary antiphospholipid syndrome and Budd-Chiari syndrome
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摘要 The antiphospholipid syndrome(APS) is an acquired thrombophilic disorder in which autoantibodies are produced to a variety of phospholipids determinants of cell membranes or phospholipid binding proteins. There are few reports about association between antiphospholipid antibodies and development of BuddChiari syndrome(BCS). We report the case of BCS development in young Russian male with primary APS. The patient underwent orthotopic liver transplantation on August 26, 2012. At present time his state is good, the blood flow in the liver restored and its function is not impaired. We report about the first time the successful use of dabigatran etexilate for prolonged anticoagulation therapy in APS patient with BCS. In addition patient is managed with immunosuppressive drugs. The antiphospholipid syndrome(APS) is an acquired thrombophilic disorder in which autoantibodies are produced to a variety of phospholipids determinants of cell membranes or phospholipid binding proteins. There are few reports about association between antiphospholipid antibodies and development of BuddChiari syndrome(BCS). We report the case of BCS development in young Russian male with primary APS. The patient underwent orthotopic liver transplantation on August 26, 2012. At present time his state is good, the blood flow in the liver restored and its function is not impaired. We report about the first time the successful use of dabigatran etexilate for prolonged anticoagulation therapy in APS patient with BCS. In addition patient is managed with immunosuppressive drugs.
出处 《World Journal of Hepatology》 CAS 2015年第19期2229-2236,共8页 世界肝病学杂志(英文版)(电子版)
基金 Supported by VA Nasonova Scientific Research Institute of Rheumatology,Moscow,Russian Federation
关键词 BUDD-CHIARI SYNDROME ANTIPHOSPHOLIPID SYNDROME INH Budd-Chiari syndrome Antiphospholipid syndrome Inh
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