血胆固醇水平对多发性骨髓瘤患者生存状况的影响

Effect of blood cholesterol levels on survival of patients with multiple myeloma

目的探索血胆固醇水平对多发性骨髓瘤患者生存状况的影响。方法选取2014-06至2017-09医院接受治疗的136例多发性骨髓瘤患者为观察组,另选取同期82例接受体检的健康者为对照组,收集患者一般资料并进行回顾性分析。结果观察组的血清总胆固醇[(2. 67±1. 12) mmol/L]、低密度脂蛋白[(1. 62±0. 98) mmol/L]、载脂蛋白B[(0. 45±0. 28) mmol/L]及高密度脂蛋白水平[(0. 81±0. 28) mmol/L],与对照组相比,差异有统计学意义(P <0. 05)。Ⅲ期患者生存率显著低于Ⅰ期和Ⅱ期,差异有统计学意义(P <0. 05)。Ig A型多发性骨髓瘤患者的低密度脂蛋白水平[(1. 38±0. 56) mmol/L]最低,轻链型多发性骨髓瘤患者的低密度脂蛋白水平[(2. 25±0. 43) mmol/L]最高,差异有统计学意义(P <0. 05)。结论多发性骨髓瘤的疾病发展状况和生存状况与血胆固醇水平有密切关系,血胆固醇水平过低导致患者病情恶化,产生较高耐药性,从而降低生存率及生存质量。

Objective To explore the effects of blood cholesterol levels on the survival of patients with multiple myeloma.Methods One hundred and thirty-six patients with multiple myeloma who were treated in the hospital between June 2014 and September 2017 were selected as the observation group,while another eighty-two healthy physical examinees were selected as the control group.Relevant data was collected and retrospectively analyzed.Results Serum levels of total cholesterol[(2.67±1.12)mmol/L],low-density lipoprotein[(1.62±0.98)mmol/L],apolipoprotein B[(0.45±0.28)mmol/L]and high-density lipoprotein[(0.81±0.28)mmol/L]were significantly lower in the observation group than in the control group(P<0.05).The survival rate of stageⅢpatients was significantly lower than that of stageⅠand stageⅡpatients(P<0.05).Low-density lipoprotein levels[(1.38±0.56)mmol/L]were the lowest in patients with Ig A multiple myeloma,but[(2.25±0.43)mmol/L]were the highest in patients with lightchain multiple myeloma(P<0.05).Conclusions The development and survival of multiple myeloma are closely related to blood cholesterol levels that depend on the intake of low-density lipoprotein.Low blood cholesterol levels can lead to the deterioration of a patient’s condition and drug resistance,which negatively affects patients’survival and quality of life.