中药泻火养阴散治疗初发毒性弥漫性甲状腺肿30例临床观察

Clinical Observation on Xiehuo Yangyin Powder in Treating 30 Initial Stage of Toxic and Diffuse Goiter Pa- tients

目的:观察中药泻火养阴散治疗初发毒性弥漫性甲状腺肿(格雷夫斯病)的治疗效果。方法:60例患者随机分为两组,治疗组(30例)用中药泻火养阴散合他巴唑治疗,对照组(30例)单用他巴唑治疗,并对两组患者治疗前及治疗后2周、4周、12周的中医症候积分及甲状腺激素水平进行分析比较。结果:治疗组治疗后2周、4周、12周的症候积分及甲状腺激素水平较治疗前下降(P<0.05或P<0.01),并优于同期对照组(P<0.05)。结论:中药泻火养阴散合他巴唑治疗格雷夫斯病,能快速、有效地改善患者的临床症状及降低甲状腺激素水平,减少他巴唑用量。

Objective: To observe the therapeutic effect of Xiehuo Yangyin powder (XHYY) in treating the initial stage of toxic and diffuse goiter (Graves' disease). Methods: Sixty patients were randomly divided into two groups, the treated group ( n = 30) was treated with XHYY and methimazole, while the control group ( n =30) was treated with methimazole alone. The TCM syndrome score and thyroxin level in the two groups were compared and analyzed before, and 2 weeks, 4 weeks, 12 weeks after treatment. Results: The syndrome score and thyroxin level in the treated group 2 weeks, 4 weeks, 12 weeks after treatment were reduced in comparing with before treatment, with the improvement better than those in the control group in the corresponding stages (P< 0.05). Conclusion: The Chinese herbal medicine XHYY plus methimazole, in treating Graves' disease, could rapidly and effectively improve the patients' clinical symptoms and lower the thyroxin level, reduce the daily taken of methimazole.