甘草饮片超微粉碎前后甘草酸溶出行为的比较研究

Comparative Study of Dissolved Matter of Glycyrrhizic Acid be fore and after Supermicro-pulverization of Radix Glycyrrhizae

目的 :考察超微粉碎前后甘草饮片中甘草酸溶出行为变化规律。方法 :以甘草酸含量为测定指标 ,分别对不同的样品进行测定实验。结果 :超微粉碎后甘草酸的溶出显著提高 ,且粉碎时间越长 ,粒度越细 ,甘草酸溶出越易。结论 :超微粉碎后有助于甘草饮片中甘草酸的溶出 ,粉碎粒度对甘草酸的溶出有显著的影响。

Objective: To investigate various ac tivities of dissolved matter of glycyrrhizic acid of Radix Glycyrrhizae and the powder by supermicro-pulver i zation. Method: The contents of glycyrrhizic acid in d ifferent samples were tested. Resu lt: The dissolved matter of glycyrrhizic acid was greatly increased by supermic ro-pulverization. The more time used for grinding, the smaller the size of t h e powder, and the easier the glycyrrhizic acid would be dissolved. Co nclusion: Supermicro-pulverization is helpful to the dissolved matter of glycyrrhizic acid of Radix Glycyrrhizae, an d the size of powder exerts great influence on dissolved matter of glycyrrhizic acid.