摘要
目的 :研究泽泻提取物不同组分对尿草酸钙结石形成的影响 ,并确定其抑制尿草酸钙结石形成的有效部位。方法 :通过喂服泽泻提取物不同组分对乙二醇和氯化铵诱导的大白鼠肾草酸钙结石模型进行实验研究。结果 :服用泽泻醋酸乙酯浸膏的醋酸乙酯洗脱液大鼠的血清尿素氮 (BUN) ,肌酐 (Cr) ,肾钙 (Ca2 + )含量 ,2 4h尿Ca2 + 分泌量 ,肾组织的草酸钙晶体沉积均明显低于成石组 (P <0 .0 5)。结论 :泽泻醋酸乙酯浸膏的醋酸乙酯洗脱液能抑制实验性高草酸尿症大白鼠体内肾草酸钙晶体的形成 。
Objective: To study the effect of differe n t extracts of Alisma orientalis on urinary calcium oxalate stone formation i n rats and to identify the ef fective constituents. Method:Different extracts were admi nistered through a stom ach tube to rats of different groups with renal calcium oxalate stones induced b y ethylene glycol (EG) and ammonium chloride (AC). Result: In the rats administe red with ethyl acetate elution of ethyl acetate extract, blood Cr, BUN,renal ti ssue calcium content,urinary calcium excretion and crystals deposition in renal tissue were significantly lower than those of the stone formation group. Conclu sion: The ethyl acetate elution of ethyl acetate fraction extract of Alisma orientalis can significantly inhibit urinary calcium oxalate stone formation in rats and be the most effective constituent of Alisma orientalis.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2003年第11期1072-1075,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金资助项目(39970 891 )
