D-氨基葡萄糖盐酸盐的抗肿瘤作用

Antitumor Effect of D-Glucosamine Hydrochloride in Mice

目的 :研究D 氨基葡萄糖盐酸盐灌胃给药 (ig)对荷瘤小鼠的抗肿瘤作用 ,考察该药对荷瘤小鼠的白细胞生成和体重有无抑制作用。方法 :采用抗移植性肿瘤实验方法 ,检测受试药物对荷瘤小鼠的瘤重、生命延长率、外周血白细胞总数、骨髓粒细胞与红细胞比值及体重的影响。结果 :D 氨基葡萄糖盐酸盐 2 0 ,10mg/kg连续给药 10d对小鼠移植肉瘤 180 (S1 80 )的肿瘤抑制率分别为 66 7%和 57 1% ;对肝癌腹水瘤 (Heps)小鼠的生命延长率分别为 2 0 8 2 %和 13 3 7% ;该药 2 0mg/kg对小鼠移植的艾氏腹水实体瘤 (EC)瘤重有显著抑制 (P <0 0 5)作用 ,10mg/kg也有一定的抑制作用 ,但与对照组比较无显著差异。高、低剂量对该模型小鼠外周血白细胞、骨髓粒细胞与红细胞比值无明显抑制作用。该药对荷瘤小鼠体重无明显影响。结论 :D 氨基葡萄糖对小鼠移植肉瘤 180 (S1 80 )、肝癌腹水瘤 (Heps)、EC腹水实体瘤有显著的抑制作用 ,该抑瘤作用属首次发现。但该药对EC腹水实体瘤小鼠白细胞生成和荷瘤小鼠体重无明显抑制作用。

AIM: To study the antit umor effect of D-Glucosamine·HCl(D-GlcN·HCl) in tumor-bearing mice by ig route. MET HOD:Weight of tumor,peripheral leckocyte count,WBC /RBC ratio of marr ow cell an d body weight were used as index which was observed to evaluate the antitumor ef fect of D- GlcN·HCl. RESULT: The results showed that tumor inhibitory r ate of D-GlcN·HCl(20,10 mg/kg) on S 180 reached 66 .7% and 57.1% respectively. It could obviously prolong the survival days of mice with Heps. Surviva l p rolong rate of Heps-bearing mice reached 208.2% and 133.7% respectively by i g D- GlcN·HCl(20,10 mg/kg). It also had good inhibitory action of on the tumor wei ght of the mice with EC and had no inhibitory effect on peripheral leukocyte,WB C/RBC ratio of bone marrow and weights of tumor-bearing mice. CONCLUS IO N: This study showed that the inhibitory effect of D-GlcN·HCl on S 180 ,Heps and EC in mice was remarkable, and it had no obvious inhib itory a ction on peripheral leukocyte,WBC/RBC ratio of bone marrow and weights of tumor -bearing mice.