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HIF与脑胶质瘤恶性度及侵袭力的关系 被引量：5

Relationship between expression of HIF and malignancy and invasiveness of human gliomas
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摘要 目的 :探讨HIF与人脑胶质瘤恶性度及侵袭力的关系 .方法 :免疫组化和原位杂交法对人脑胶质瘤病检标本研究 ,从转录和蛋白表达水平研究HIF在不同级别胶质瘤细胞中的表达情况 .结果 :不同级别的胶质瘤HIF表达情况不同 ,级别高的肿瘤HIF表达高于级别低的肿瘤 ,以高度恶性胶质瘤最为显著 ;HIF表达与Ki 6 7有密切相关性 .结论 :HIF在胶质瘤中表达与肿瘤恶性度及侵袭性有明显的相关性 ,提示HIF可能是激发实体胶质瘤发展及复发的因素之一 . AIM: To study the relationship between the expression of HIF (hypoxia inducible factor) and the malignancy and invasiveness of human gliomas. METHODS: Seventy biopsy specimens of glioma patients were studied by immunohistochemistry and in situ hybridization techniques. The transcription and expression of HIF gene were investigated in each grade of gliomas. RESULTS: The expressions of HIF were different in gliomas from Ⅰ to Ⅳ grades and the expression of HIF was stronger in high grade gliomas than that in the low. The top malignant glioma showed noted expression of HIF and the expression of HIF was correlated with Ki 67. CONCLUSION: There is a significant correlation between the expression level of HIF and the tumor malignancy and invasiveness, suggesting that HIF may be one of the positive factors to promote glioma development and recurrence.
作者 王彦刚 章翔 付洛安 费舟 刘卫平 王占祥 张剑宁
机构地区 第四军医大学西京医院全军神经外科研究所
出处 《第四军医大学学报》 北大核心 2003年第22期2034-2036,共3页 Journal of the Fourth Military Medical University
基金 国家自然科学基金资助项目 (39970 852 )
关键词 神经胶质瘤 低氧诱导因子 侵袭力 恶性度 HIF 免疫组化法 原位杂交法 glioma hypoxia inducible factor invasiveness malignancy
分类号 R730.264 [医药卫生—肿瘤] R730.2 [医药卫生—肿瘤]
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参考文献14

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同被引文献56

  • 1张倜,孙惠川,汤钊猷.肿瘤血管异质性及其研究意义[J].国外医学（肿瘤学分册）,2005,32(2):94-97. 被引量：4
  • 2秦华平,熊光仲,肖惠生.脑胶质瘤中缺氧诱导因子-1α的表达及与肿瘤分级的相关性[J].中华神经医学杂志,2005,4(4):348-350. 被引量：6
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引证文献5

二级引证文献10

第四军医大学学报
2003年 第22期

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