乙型肝炎病毒携带者妊娠对新生儿的影响探讨

A study on the influence of hepatitis B virus carrying pregnancy on the newborn

目的 :探讨乙型肝炎病毒慢性携带者妊娠对新生儿的影响。方法 :检测 66例 HBs Ag阳性产妇静脉血、脐血、乳汁中 HBV DNA含量并对其分娩及新生儿指标进行分析。结果 :脐血 HBV DNA阳性率为 59.1% ;产妇血 HBVDNA含量与脐血 HBV DNA含量的相关系数为 0 .3 72 (P<0 .0 5) ,呈正相关 ;产妇血、脐血 HBV DNA含量与新生儿体重无关 ,有新生儿窒息与无新生儿窒息者比较 ,产妇血、脐血 HBV DNA含量均无显著性差异。结论 :乙型肝炎病毒慢性携带者妊娠可造成新生儿乙型肝炎病毒感染 ,孕妇分娩前的感染状况不能反映其对胎儿发育。

The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou To study the influence of hepatitis B virus carrying pregnancy on t he newborn,H BV DNA in venous blood,umbilical blood and breast-milk of 66 HBsAg positive pre gnant women were detected and the data about delivery and newborn were analyzed. Results showed that the umbilical HBV DNA positive rate was 59.1%,the relative ratio between the value of maternal venous HBV DNA and that of umbilical HBV DN A was 0.372(P=0.003).No relationship between the value of maternal venous HBV DA N and the neonatal body weight was observed. Neither was the relation between th e value of umbilical HBV DNA and the neonatal body weight. No significant differ ence was showed in the value of maternal venous HBV DNA and that of umbilical HB V DNA between the newborn with asphyxia and those without asphyxia. We draw the conclusion that hepatitis B virus carrying pregnant women can cause the infectio n of their newborn and the maternal infectious data before delivery can not impl icate the fetal growth and the placenta function.