S-100吸收性止血绫于兔皮肤、皮瓣移植术中的应用观察

Application of S-100 absorbent hemostatic satin in transplantations of full-thickness skin and random flap in rabbits

目的:观察S-100吸收性止血绫于家兔皮肤、皮瓣移植术中的止血效果及其对移植皮肤、皮瓣成活的影响。方法:于普通级成年家兔背中线两侧行皮肤和皮瓣移植术,一侧创面覆盖S-100止血绫,随即行皮肤、皮瓣移植,另一侧则实施机械性压迫,待出血停止后再做皮肤、皮瓣移植,观察两种方法的止血效果及皮肤、皮瓣的成活情况;术后2、4周取材,观察止血绫的残留量、组织反应程度。结果及结论:S-100吸收性止血绫起效速度及止血效果均优于机械性压迫,组织反应轻,对移植皮肤、皮瓣成活无明显影响,有于临床应用的可能性。

Objective:To investigate the effects of S-100absorbent hemostatic satin using on the oozing wound surface,the survival of full-thickness skin graft and various flap transplantation in rabbits.Method:A3×3cm 2 full-thickness skin flap were harvested on both sides from the back of12rabbits.Laying S-100absorbent hemostatic satin in between the donor skin and the recipient area as the means of reducing bleeding on each side of the middle line,leaving the material in place.Dresing alone without satin was taken as control on the other side to observe the hemostatic effectiveness,survival of the skin and also foreign body deposit,tissue reaction with histological study.Result and Conclusion:S-100absorbent hemostatic satin manifested hemostatic effectiveness,mild tissue reaction and no adverse influence to skin survival,and would be valuable in clinical application.