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齐多夫啶半乳糖神经酰胺脂质体的制备及理化性质研究 被引量:1

The preparation of azidothymidine liposomes containing galactosylceramide and the observation of it's physico-chemical properties
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摘要 目的 制备齐多夫啶半乳糖神经酰胺脂质体并对其理化性质进行研究。方法 采用两次乳化法 ,以半乳糖神经酰胺为主要膜材制备齐多夫啶半乳糖神经酰胺脂质体并进行形态学观察、检测其包封率和稳定性。结果 透射电子显微镜下观察齐多夫啶半乳糖神经酰胺脂质体为粒径均匀的球形或近球形的小单层颗粒 ;粒径范围为 6 0~ 2 70nm ,D5 0为 1 4 0nm ;包封率达72 5 % ,但 1 0d后快速下降。结论 齐多夫啶半乳糖神经酰胺脂质体制备方法可行 。 AIM To prepare azidothymidine liposomes containing galactosylceramide and to observe it's physico chemical properties. METHODS The liposomes was prepared by double emulsion and it's morphology, entrapment ratio and stability were observed. RESULTS The results of electron micrography showed that the liposomes was consisted of spherical or similar to spherical small unilamellar vesicles, the size was 60~270 nm and its D50 was 140 nm. The entrapment ratio were up to 72 5%, but it was rapidly descended after 10 d. CONCLUSIONS The preparation of azidothymidine liposomes is practicable. The entrapment ratio and stability shoud be raised.
出处 《安徽医药》 CAS 2003年第6期420-422,共3页 Anhui Medical and Pharmaceutical Journal
基金 卫生部科学研究基金资助课题 (98- 1 - 336)
关键词 齐多夫啶 半乳糖神经酰胺 脂质体 制备方法 理化性质 艾滋病 galactosyceramide liposomes physico chemical properties
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  • 1戎隆富 秦德安.包封有天花粉蛋白的半乳糖神经酰胺脂质体的制备及性质研究[J].华东师范大学学报,1997,12:6-11.

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