脾肾两助丸抗抑郁作用的实验研究

Experimental Research on Antidepressant Function of Pishen Liangzhu Wan

目的:观察逍遥丸、甘麦大枣汤、养血归脾丸、脾肾两助丸等中药复方的抗抑郁药效结果。方法:以小鼠强迫游泳法、悬尾法制造抑郁模型,将动物随机分为正常对照组、逍遥丸组、甘麦大枣汤组、养血归脾丸组、脾肾两助丸组,观察中药复方对小鼠自主活动、强迫游泳不动时间、悬尾不动时间的影响。结果:逍遥丸、甘麦大枣汤、养血归脾丸对小鼠的自主活动、强迫游泳不动时间、悬尾不动时间均无影响;脾肾两助丸可增加小鼠的自主活动,明显缩短小鼠强迫游泳不动时间、悬尾不动时间(P<0.01)。结论:脾肾两助丸有明显的抗抑郁作用。

Objective:To observe the antidepressant function of complex prescriptions.Methods:The models were made by forced swimming text and tail suspended test on the mice.The mice were divided into controlled group , Xiaoyao wan group,Ganmai Dazao group,Yangxue Guipi wan group and Pishen Liangzhu wan group randomly,then observed the effect of the complex prescriptions on the mice′ s spontaneous activity,forced swimming accumulative immobility time and tail suspended accumulative immobility time.Results:Xiaoyao wan、 Ganmai Dazao decoction、 Yangxue Guipi wan had no effect on the three tests,and Pishen Liangzhu wan could rise the spontaneous activity of the mice,also reduced the accumulative immobility time in the forced swimming test and tail suspended test(P<0.01).Conclution:Pishen Liangzhu wan had obvious effects on depression.