妇宝胶囊止血机制的实验研究

Experimental Research of Fubao Capsule on the Hemostatic Mechanism

目的:通过观察妇宝胶囊对动物出凝血时间、血液凝固系统的影响,探讨妇宝胶囊的止血机制。方法:采用毛细玻璃管法测定小鼠凝血时间(CT),用断尾法测定出血时间(BT);用ACL-200型血液凝集仪测定大鼠凝血酶原时间(PT)和部分凝血活酶时间(APTT)。结果:妇宝胶囊能明显缩短小鼠CT、BT,缩短大鼠PT和APTT。结论:妇宝胶囊的止血机制主要通过促进内源性和外源性凝血系统,抑制纤维蛋白溶解系统达到目的。

Objective: To probe the hemostatic mechanism of Fubao capsule through observing its influence on the coagulation time(CT), bleeding time(BT) and blood coagulation system.Methods:CT was measured by capillary method and BT was measured by cutting tail method.The prothrombin time(PT) and the active partial thromboplastin time(APTT) were measured by the ACL- 200 antomatic blood agglutination instrument.Results: Fubao capsule could obviously reduce the BT,CT,PT,and APTT of model rats.Conclusion:The main hemostatic mechanism of Fubao capsule was to stimulate the intrinsic and extrinsic blood coagulation system and to inhibit fibrinolysis system.