探讨神经节苷酯治疗新生儿缺氧缺血性脑病效果

Exploration on the effect of ganglion glucoside ester in treatment of neonatal hypoxic ischemic encephalopathy

目的探讨神经节苷酯治疗新生儿缺氧缺血性脑病的治疗效果。方法将2012年3月~2013年3月收治的90例新生儿缺氧缺血性脑病患儿按入院时间随机分为两组,各45例,对照组采用综合治疗,研究组在综合治疗的基础上增加使用神经节苷脂治疗。结果新生儿缺氧缺血性脑病患儿研究组45例,治疗显效39例,占86.67%,好转4例,占10%,无效2例,占4.44%。对照组45例,显效30例,占66.66%,好转7例,占17.78%,无效8例,占15.56%。研究组总有效率95.56%高于对照组总有效率为84.44%,差异有统计学意义(χ2=4.05,P【0.05)。结论应用神经节苷脂治疗新生儿缺氧缺血脑病安全有效,值得推广使用。

Objective To study the treatment effect of ganglion glucoside ester in treatment of neonatal hypoxic ischemic encephalopathy.Methods From March 2012 to March 2012, there were treated 90 cases of neonatal hypoxic ischemic encephalopathy patients according to admission time were randomly divided into two groups (45 cases, control group adopts comprehensive treatment, the team on the basis of comprehensive treatment increased use of ganglioside treatment.Results Children with neonatal hypoxic ischemic encephalopathy group 45 cases, treatment of 39 cases had marked effect, 86.67%, improvement in 4 cases, account for 10%, ineffective in 2 cases, accounted for 4.44%. Control group 45 cases, 30 cases were markedly effective, accounted for 66.66%, improvement in 7 cases, accounted for 17.78%, 8 cases, accounting for 15.56%. Group total effective rate 95.56% higher than the control group the total effective rate was 95.56%, the difference is statistically significant (χ2=4.05,P<0.05).Conclusion Application of ganglioside in treatment of neonatal hypoxic ischemic encephalopathy is safe, worthy of promotion of use.