锌指转录调节蛋白KLF4在喉鳞状细胞癌组织中的表达及意义

Expression and significance of zinc finger transcription adjection protein in laryngeal squamous cell carcinoma

目的检测锌指转录调节蛋白KLF4在喉鳞状细胞癌组织中的分布、表达及其与临床特征的关系。方法采用免疫组化染色法检测并分析KLF4在48例经病理确诊为喉鳞状细胞癌组织中的分布及表达,以56例声带息肉组织作为对照。结果 KLF4蛋白在喉鳞状细胞癌及声带息肉组织的表达差异有统计学意义。同时,高分化鳞癌与低分化鳞癌的表达差异有统计学意义。结论 KLF4可能在喉鳞状细胞癌的发生发展中起了重要作用,并且可能主导了肿瘤的分化程度。

objective To investigate the relation of distributions and expressions of the zinc finger transcription adjection protein KLF4 with clinical histological characteristics in laryngeal squamous cell carcinoma(LSCC).Methods The distributions and expressions of KLF4 were examined with immunohistochemical staining in 53 specimens which were diagnosed by pathology , and comparing with 44 specimens of polyp of vocal cord(PVC).Results The differences of expressions of KLF4 between LSCC and PVC were statistically significant(P<0.05).At the same time, the differences between well-differentiated and pooly-differentiated laryngeal squamous cell carcinoma were statistically significant also(P<0.05).Conclusion KLF4 may play a important role in the generation and evolution of LSCC, and decide the differentiation degree of LSCC.