多烯大环内酯类抗生素生物合成基因簇中调控因子的研究进展

Research progress of regulators in polyene macrolide antibiotic biosynthetic gene clusters

多烯大环内酯类抗生素具有良好的抗真菌活性,广泛应用于医疗卫生、食品加工和农业生产领域。随着高通量测序技术和生物信息学技术的发展,越来越多的链霉菌抗生素生物合成基因簇被发现和鉴定,调控因子作为生物合成基因簇中的重要组成部分,在庞大复杂的调控网络中起着至关重要的作用。本文总结了链霉菌中重要的调控因子类型,综述了多烯大环内酯类抗生素生物合成基因簇中调控因子的生物学功能、结合位点、作用机制等研究进展,并展望了后续研究工作。

Polyene macrolide antibiotics,as effective antifungal agents,are widely used in the treatment of fungal infections,food preservatives and agricultural aspects.With the development of next-generation sequencing technology and bioinformation,numerous antibiotic biosynthetic gene clusters of Streptomyceshave been identified.A variety of regulators encoded by regulatory genes play a crucial role in the regulatory network of Streptomyces.This article summarizes the important types of regulatory factors of Streptomyces and reviews the progress of regulatory factors of the biosynthetic gene cluster of polyene macrolide antibiotics.Combining with the functions of regulatory factors,structural binding site and regulatory mechanisms,the potential relationship and research are summarized and prospected.