真菌来源的药用天然产物

Natural medicinal products of fungal origin

天然产物及其衍生物,包括基于天然产物药效基团结构设计的化合物,约占临床药物的50%以上。几个世纪以来,真菌天然产物的药用价值闻名于世。无论从市场前景还是人道主义角度,真菌来源的小分子药物都具有极高的应用价值。本篇综述总结了真菌天然产物在临床上的应用,并以他汀类药物的研发历程揭示了真菌来源小分子是化学合成药物研发的重要灵感源泉。本篇综述涵盖了真菌来源的药物小分子,包括天然药物、相关衍生物以及结构修饰药物。

Natural products and their derivatives,including the compounds designed based on the structure of natural product pharmacophores,account for more than 50%of approved drugs.The medicinal value of fungal natural products has been known for centuries,and millions of patients worldwide have been treated with fungal-derived small molecule drugs every year.Fungal-derived small molecule drugs are very valuable,both in terms of market prospects and humanitarian perspectives.This review summarizes the clinical application of fungal natural products,and the development of statins reveals that fungal-derived natural products are an important source of inspiration for drug synthesis in the 21 st century.This review covers small molecules of fungal-derived drugs,including natural drugs,related derivatives,and structurally modified drugs.