亚洲甲型流行性感冒病毒的生物学性状研究 Ⅲ.毒性反应及发热反应

STUDIES ON THE BIOLOGICAL CHARACTERISTICS OF THE ASIAN A TYPE INFLUENZA WRUS Ⅲ.TOXICITY AND PYROGENICITY TO EXPERIMENTAL ANIMALS

关于流感病毒的毒性作用,Henle等已报告过原甲型、猪型及乙型流感病毒脑内注射均可引起小白鼠抽搐死亡。Evans报告甲、乙型流感病毒可引起家兔角膜混浊反应。上述作者们证实引起这些反应的物质和病毒颗粒不能分离开,并认为流感病毒的毒性大小在引起流感的临床症状的轻重程度上有重要的意义。 Bennett等仔细观察过流感病毒引起的家兔发热反应,并证实引起发热反应的性质是与病毒颗粒相结合的,加温62℃30分钟或先用霍乱弧菌滤液注射家兔。

1. The Asian A type influenza virus, which had been passed through embryonatedeggs up to the 6th passage, caused corneal turbidity after inoculation into the anteriorchamber of rabbits. However, this reaction became irregular when the 20th passagevirus was employed. The reaction produced after reinoculation of the virus at the samesite was also irregular and subsided quickly. 2. When injected intravenously into rabbits, the 6th passage virus caused a rise intemperature which was characterized by a two-peak fever curve, while the injection ofa 20th passage virus caused only one-peak fever curve. A prime strain also gave anone-peak fever curve.