亚洲甲型流行性感冒病毒的生物学性状研究 Ⅳ.动物感染实验

STUDIES ON THE BIOLOGICAL CHARACTERISTICS OF THE ASIAN A TYPE INFLUENZA VIRUS Ⅳ.EXPERIMENTAL INFECTION IN ANIMALS

已有的文献报告证明雪貂是一种对流感病毒敏感的动物,但此种动物大量繁殖饲养比较困难。多数流感病毒株在小白鼠中连续传代可获得适应,到目前为止,它是唯一的能较广泛应用于流感病毒研究的动物,但适应毒株在小鼠中引起的疾病是病毒性肺炎,与人的流感在各方面都不相同。力此寻求新的对流感病毒敏感的实验动物是迫切需要的。故我们试验了8种实验室常用动物对新分离的亚洲甲型流感病毒的敏感性,除了观察这些动物在感染后的临床症状和抗体产生情况外,并用其鼻洗液或肺组织作病毒分离试验。本文即报告这些试验的结果。

Results of intranasal instillation of the Asian A type influenza virus to variousanimals showed that young puppies developed mild fever and upper respiratory inflam-matory signs, while young cats, cotton-rats, Chinese hamsters, suckling guinea pigs,suckling white rats and suckling mice manifested as inapparent infection which was de-monstrated by survival of the virus in the upper respiratory tract of these animals forseveral days and the production of antibody. The possibility of application of theseanimals to experimental studies of influenza virus was briefly discussed.