摘要
体外实验证明,同时加入小于抑菌浓度的氯丙嗪,可提高青霉素对一定菌量的耐药金黄色葡萄球菌的杀菌力;但对敏感菌株则作用不明显。这种合并用药的效果可以由菌的生长曲线表达出来。氯丙嗪20微克/毫升加入小于抑菌浓度的青霉素,在7小时后菌数已经减低,菌液中的青霉素量并未减少;不加氯丙嗪者则在7小时后菌数逐渐增高,此时菌液中的青霉素已全部破坏。可能是氯丙嗪影响了青霉素酶的活性或生成。这个结果可能在解决金黄色葡萄球菌的耐药性上提供线索。
A combination of sub-bacteriostatic dose ofchlorpromazine(20r/ml)with sub-bacteriostaticdose of penicillin(32,16 or 8u/ml)showedsynergism against penicillin-resistant strain of Staph.aureus.After 48 hours of incubation,no viablecells were found.However this synergism was notdemonstrated against penicillin-sensitive strain. It was suggested that chlorpromazine probablyinhibited the activity or production of penicillinaseby the penicillin-resistant strain.
出处
《微生物学报》
CAS
1966年第1期50-54,共5页
Acta Microbiologica Sinica
