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极端嗜热古菌DNA修复核酸内切酶的研究进展 被引量:2

Research progress of hyperthermophilic archaeal DNA repair endonucleases
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摘要 极端嗜热古菌由于生活在高温环境,其基因组DNA面临着严重的挑战,因此,它们如何维持其基因组稳定是本研究领域最为关注的科学问题之一。极端嗜热古菌具有与常温微生物相似的自发突变频率,暗示着它们比常温微生物具有更加有效的DNA修复体系进行修复高温所造成的基因组DNA损伤。目前,极端嗜热古菌DNA修复的分子机制尚不清楚。核酸内切酶在DNA修复途径中发挥着重要的作用。基因组序列显示极端嗜热古菌编码多种DNA修复核酸内切酶,但是其研究尚处于初期阶段。本文综述了极端嗜热古菌DNA修复核酸内切酶Nuc S、Endo V、Endo Q、XPF和Hjc的研究进展,并对今后的研究提出了展望。 Hyperthermophilic archaea are facing severe challenges due to their high temperature environment.Therefore,how to maintain genomic stability of hyperthermophilic archaea is one of the most important scientific questions in this field.Hyperthermophilic archaea have similar spontaneous mutation frequencies to mesophilic microorganisms,suggesting that they have a more efficient DNA repair system than mesophilic microorganisms to repair genomic DNA damage caused by high temperature.At present,the molecular mechanism of DNA repair of hyperthermophilic archaea is still unclear.Endonucleases play an important role in the DNA repair pathway.Genomic sequences show that hyperthermophilic archaea encode a few DNA repair endonucleases,however,the research on them is still in an early stage.In this paper,we reviewed the research progress of hyperthermophilic archaeal DNA repair endonucleases,including Nuc S,Endo V,Endo Q,XPF and Hjc.We also proposed future studies.
作者 李玉婷 史昊强 张立奎 Yuting Li;Haoqiang Shi;Likui Zhang(Marine Science&Technology Institute,Department of Environmental Science and Engineering,Yangzhou University,Yangzhou 225127,Jiangsu Province,China)
出处 《微生物学报》 CAS CSCD 北大核心 2019年第10期1889-1896,共8页 Acta Microbiologica Sinica
基金 扬州大学中青年学术带头人项目 江苏省大学生科技创新项目(201711117059Y)~~
关键词 极端嗜热古菌 核酸内切酶 DNA修复 hyperthermophilic archaea endonuclease DNA repair
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