微创放射粒子植入综合治疗肺癌

Minimally invasive brachytherapy in the combination treatment of lung cancer

目的 研究以微创手术、放射性粒子植入为基础综合治疗肺癌的方法和疗效。 方法 2 0 0 0年 1 1月～ 2 0 0 2年2月 ,1 2例肺癌 (其中原发肺癌 4例 ,复发性肺癌 3例 ,转移性肺癌 5例 ) ,采用胸腔镜辅助小切口 ,行肿瘤局部楔形切除联合粒子植入 5例 ,射频热疗联合粒子植入 3例 ;经皮穿刺射频治疗联合粒子植入 3例 ,单纯粒子植入 1例 ,术后根据全身情况行综合治疗。 结果 随访 1 2月～ 30月 ,全组局部控制率为 83% ,均已存活 1年以上 ,2例死亡 (1 8月 ,2 1月 )。所有病人无白血球、血小板降低。 结论 以微创手术及粒子植入为基础的综合治疗有较高的局部控制率 ,生活质量高 。

Objective To study the method and effect of the combination treatment based on the minimally invasive surgery and radioactive seeds brachytherapy for lung cancer. Methods Entered the study there were 12 cases of lung cancer (4 cases of primary lung cancer, 3 cases of recurrent lung cancer, and 5 cases of metastatic lung cancer) between November 2001 and February 2002. All the 12 patients received thoracoscopic mini operations, including 5 cases of local wedge-shaped tumor resection combined with seeds implantation, 3 cases of radio frequency thermaerotherapy combined with seeds implantation, 3 cases of percutaneous radio frequency with seeds implantation, and 1 case of seeds implantation only. Postoperative combination treatment was conducted in accordance with the patient's general condition. Results All the patients were followed for (12～30) months. The local control rate in the study was 83%, and the survival time was more than 1 year. Two patients expired in the 18th and 21st postoperative months, respectively. No decreases of the white blood cell and platelet took place. Conclusions The combination treatment based on minimally invasive surgery and radioactive seeds brachytherapy provides high local control rate, high life quality and satisfactory survival time.