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细胞内信号转导分子——Smad7在人牙胚发育中的表达和意义 被引量：2

The Expression and Function of Smad7 During Human Tooth Germ Development
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摘要 目的　探讨Smad7在TGF_β调节牙胚发育过程中的作用。方法　采用免疫组化ABC法观察Smad7在人牙胚发育各个时期的表达分布及其变化情况。结果　人牙胚发育各个时期均表达Smad7,但各期分布模式有所不同。Smad7在不同发育时期牙胚中的分布与TGF_β及其特异的信号转导分子Smad2、3有相似之处。 结论　Smad7可能在TGF_β调节成釉细胞和成牙本质细胞分化的信号转导通路中起一定的作用。 Objective To observe the temporal and spatial expression of Smad7 during human tooth germ development and evaluate the effect of Smad7 on tooth germ development.Methods The expression of Smad7 and its changes at different stages of human tooth germ were detected by using immunohistochemical staining.Results Smad7 was expressed at all stages of tooth germ, but the distribution patterns at various stages were different. It indicated that temporal and spatial expressing mode of Smad7 during human tooth germ development was specific, which was similar to that of TGF-β and its signal transducer Smad2/3.Conclusion Smad7 might play an important role in TGF-β intracellular signaling for modulating the differentiation of ameloblasts and odontoblasts.
作者 包柳郁 牛忠英 史俊南 汪平
机构地区 第四军医大学口腔医院牙体病科 解放军
出处 《华西口腔医学杂志》 CAS CSCD 北大核心 2003年第6期438-440,共3页 West China Journal of Stomatology
基金 国家自然科学基金资助项目 (编号 39870 789)
关键词 细胞内 信号转导分子 SMAD7 人牙胚发育 表达 免疫组织化学 Smad7 tooth germ development immunohistochemistry
分类号 R780.2 [医药卫生—口腔医学]
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参考文献6

  • 1Martin A;Unda FJ;Begue-Kirn C.Effects of aFGF,bFGF,TGF-β1 and IGF-1 on odontoblast differentiation in vitro,1998(Suppl 1).
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二级参考文献8

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共引文献4

同被引文献16

  • 1Mori Y, Chen SJ, Varga J. Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-beta. Exp Cell Res, 2000, 258(2): 374-383.
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华西口腔医学杂志
2003年 第6期

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