尿酸在子痫前期发病机制中的相关性研究进展

The involvement of uric acid in the pathogenesis of preeclampsia

子痫前期是妊娠期常见疾病,是全球孕产妇和新生儿发病和死亡的主要原因。高尿酸血症是子痫前期一个重要生化特征,通常尿酸水平升高被认为是子痫前期肾功能障碍的结果,但早在妊娠第10周就发现子痫前期患者尿酸水平升高,尿酸通过干扰子宫螺旋动脉重铸,导致氧化应激,促进内皮功能损害及炎症反应,减少一氧化氮形成,促进了疾病的发生发展。

Preeclampsia is a common disease in pregnancy and a major cause of maternal and neonatal morbidity and mortality.Hyperuricemia is an important biochemical feature of preeclampsia.Traditionally,elevated uric acid levels are considered to be the result of preeclampsia renal dysfunction.However,elevated uric acid levels were found in preeclampsia patients as early as 10 weeks of pregnancy.Uric acid can lead to oxidative stress by interfering with the reconstruction of the uterine spiral artery,promote endothelial function damage and inflammation and reduce NO formation.It promotes the occurrence and development of disease.