2型糖尿病中医辨证分型与血清骨钙素、甲状旁腺素水平的相关性研究

Study on Relationship between TCM Syndrome-Type and the Levels of Serum Bone GLA-protein Osteocalcin (BGP),Parathyroid Homone(PTH) in Type 2 Diabetes Mellitus

目的 :观察 2型糖尿病中医辨证分型与血清骨钙素 (BGP)、甲状旁腺素 (PTH)的关系 ,为中医辨证分型提供客观依据。方法 :将 6 0名 2型糖尿病患者辨证分为阴虚热盛型组、气阴两虚型组、阴阳两虚型组 ,并另设一个健康对照组 ,测定各组的血清骨钙素、甲状旁腺素水平 ,并进行比较。结果 :2型糖尿病组血清骨钙素、甲状旁腺素水平显著高于健康对照组 (P<0 .0 1) ;各证型组之间 ,阴阳两虚型组血清骨钙素显著低于气阴两虚型组及阴虚热盛型组 (P<0 .0 5 ,P<0 .0 1) ,甲状旁腺素显著高于阴虚热盛型组 (P<0 .0 5 ) ,气阴两虚型组血清骨钙素显著低于阴虚热盛型组 (P<0 .0 5 )。结论 :血清骨钙素、甲状旁腺素的水平可能反映了 2型糖尿病各中医证型“肾虚”的程度 ,有可能成为

Objective:To observe the relationship between TCM Syndrome-type and serum BGP,PTH in diabetes mellitus type 2 and disclose the objective material base of TCM Syndrom-type of type 2 diabetes mellitus so as to supply objective basis for TCM syndrome-type as well as to promote the devolopment of syndrom-type of diabetes in order to make it more objective and more standardized.Methods:Sixty patients with type 2 diabetes mellitus were divided into three groups according to the Syndrome Differentiation-typing in TCM,the Yin deficiency and high fever group,both Qi-Yin deficiency group and both Yin-Yang deficiency gruop,and a healthy control group was designed.The BGP and PTH of the four groups mentioned above were determined and compared.Results:The levels of serum BGP and PTH of the patients with type 2 diabetes mellitus were significantly higher than those of the healthy control group(P<0.01);Among the former three gruops,the serum BGP of both Yin-Yang deficiency group was significantly lower than those of both Qi-Yin deficiency group and Yin deficiency and high fever group (P<0.05,P<0.01),and its PTH was significantly higher than that of Yin deficiency and high fever group(P<0.05).the serum BGP of both Qi-Yin deficiency group was significantly lower than that of Yin deficiency and high fever group(P<0.05).Conclusion:The level of serum BGP and PTH probably reflected the degree of various renal deficiency of TCM Syndrom type in patients with type 2 diabetes mellitus,and was hopeful to be the objective quota of TCM Syndrome type 2 diabetes mellitus.