脐血血清转铁蛋白受体浓度与母亲贫血关系的研究

Research the relationship between neonatal cord serum transferrin receptor concentrations and maternal iron deficiency.

【目的】 通过检测新生儿脐血中可溶性血清转铁蛋白受体 (serumtransferrinreceptor ,sTfR)的浓度 ,研究母亲贫血对新生儿的影响 ,为早期新生儿缺铁性贫血的诊断提供一个有用的预测性指标。 【方法】 采用酶联免疫试剂盒测定了由 3 0例贫血妊娠妇女 ,48例健康妊娠妇女分娩的新生儿体内的sTfR水平 ,并对实验数据进行了分析。 【结果】 3 0例贫血妊娠妇女分娩的新生儿的sTfR平均值 ( 3 2 .2 4± 8.0 8)nmol/L显著高于临界值 2 8.10nmol/L(P <0 .0 1) ,属于缺铁性贫血范围 ;48例由正常妊娠妇女分娩的新生儿的sTfR平均值 [( 2 5 .5 5± 9.69)nmol/L]接近临界值 2 8.10nmol/L(P >0 .0 5 ) ,属于正常范围。贫血妊娠妇女分娩新生儿的sTfR水平明显高于正常妊娠妇女分娩新生儿的sTfR水平 (P <0 .0 1)。 【结论】 缺铁性贫血母亲分娩新生儿的sTfR值偏高 。

The neonatal cord serum transferrin receptor(sTfR) had been shown to be useful as early indicators of iron deficiency.The effect of maternal iron deficiency on neonates was researched. 78 blood samples were collected from 30 infants produced by mother with iron deficient anemia and 48 infants produced by normal mother, and the plasma were measured with ELISA for the levels of sTfR and the data was analysed. In 30 infants produced by mother with iron deficient anemia, the mean of sTfR was (32.24±8.08) nmol/L , which was higher than the normal level (28.10 nmol/L) ( P <0.01). In 48 infants produced by normal mother, the mean of sTfR was (25.55±9.69) nmol/L , which was approximately equal to normal level ( P >0.05). The median of sTfR between the two groups had markedly differences( P <0.01).[Conclusions] The mean of sTfR of infants born by mother with iron deficient being higher.The result showed that sTfR might to be a reference index for diagnosis of iron deficiency in infants.