骨髓来源免疫抑制细胞参与肿瘤进展的相关信号通路

Signaling pathways involved in myeloid derived suppressor cells promoting tumor growth

骨髓来源免疫抑制细胞(myeloid derived suppressor cells,MDSCs)是一群异质性的骨髓来源的未成熟前体细胞,它们在肿瘤微环境中大量聚集,阻碍T细胞的抗肿瘤免疫应答反应。MDSCs的产生、聚集和发挥促肿瘤功能依靠STAT3、IL-1β/NF-κB、PI3K/AKT/m TOR、PGE2/Cox2及RAS信号通路的调节,信号通路的调节紊乱导致骨髓造血功能异常,形成具有免疫抑制功能的骨髓来源细胞,在肿瘤间质中聚集形成免疫抑制微环境。了解这些信号通路,特别是STAT3信号通路,能帮助我们理解恶性肿瘤中MDSCs功能的分子机制,找到一些消除肿瘤微环境中MDSCs的方法。

Myeloid derived suppressor cells(MDSCs) represent a population of heterogeneous myeloid cells that are at early stages of development. There is an accumulation of MDSCs in tumor microenvironment. The generation of MDSCs can counteract T cell responses. Generation, expansion and playing a role in promoting tumor of the MDSCs rely on signaling pathways such as STAT3, IL-1β/NF-κB, PI3K/AKT/m TOR, PGE2/Cox2 and RAS. Perturbation of signaling pathways involved during normal hematopoietic and myeloid development, leading to the generation and accumulation of suppressive MDSCs and immunosuppressive tumor microenvironment. Targeting these pathways should help in elucidating mechanisms that lead to the expansion of MDSCs in cancer and point to methods for eliminating these cells from the tumor microenvironment, especially the STAT3 signaling pathway.