2014年长沙地区16395例儿童维生素D水平分析

Analysis of the vitamin D level among 16395 children in Changsha area in 2014

目的:比较分析长沙地区部分儿童维生素D水平,为临床合理补充维生素D、改善儿童户外活动习惯以促进维生素D的合成提供科学依据。方法:收集我院2014年长沙地区16395例0~12岁健康体检儿童血清标本,通过酶联免疫吸附试验(ELISA)方法检测血清25-羟基维生素D[25-hydroxyvitamin D,25-(OH)D],采用单因素方差分析等统计学方法全面分析了不同年龄、性别以及一年中不同月份维生素D水平差异。结果:0~12岁儿童血清25-(OH)D平均水平为(59.2±24.5)nmol/L,远低于充足水平;<1月婴儿组与1~2月婴儿组间差异无统计学意义、学龄前组组与学龄组间差异无统计学意义(P>0.05),其他各组间差异均有统计学意义(P<0.05);不同性别间血清25-(OH)D水平差异无统计学意义(P>0.05);一年中10月份血清25-(OH)D水平最高,平均值为(68.5±24.8)nmol/L,1~10月水平呈逐步上升趋势,11月、12月又逐步下降。结论:长沙地区儿童需要增加户外活动时间,延长维生素D补充摄入时间,用以改善维生素D缺乏与不足的普遍现象。

Objective: Analyzing the vitamin D level of children in Changsha area, to provide theoretical basis for clinical vitamin D supplement and improvement of vitamin D synthesis through outdoor activities. Methods:The serum samples of 0~12 years old healthy children of Changsha area in 2014 were collected. Serum 25-hydroxyvitamin D [25-(OH)D] concentrations were determined by ELISA kits.The differences of serum 25-(OH)D from different ages, gender, and months among a year were analyzed by One-Way ANOVA. Results:The average 25-(OH)D level of 0~12 years old healthy children was(59.2±24.5) nmol/L, far below the adequacy standards of >75 nmol/L. There was no statistical different between <1 month old infant group and 1~2 months old infant group(P>0.05). There was no statistical difference between preschool age group and school age group(P>0.05). There was statistical different between other groups(P<0.05). In 2014, the highest 25-(OH)D level appeared in October, was(68.5±24.8) nmol/L. The value of serum 25-(OH)D gradually increased from January to October, and then went down in November and December. Conclusion: Children in Changsha area needed to have more outdoor activities, and extend vitamin D supplement intake time, so that ameliorate the common phenomenon of vitamin D deficiency.