48例干燥综合征妊娠妇女妊娠结局的临床分析

Clinical analysis of pregnancy outcome in 48 pregnant women with Sjogren's syndrome

目的:探讨干燥综合征(Sjogren’s syndrome,SS)妊娠期妇女对胎儿和妊娠结局的影响。方法:选择48例SS的妊娠妇女为研究对象,同时选取96例年龄和BMI与之相匹配的正常人群为对照组,根据患者妊娠前有无规律治疗,分为规律治疗组和未规律治疗组,分析SS与不良妊娠的关系。结果:SS患者分娩明显早于对照组(38周+3 d vs 39周+2 d),自然流产的发生率更高(27%vs 9%,P=0.001)。SS组早产率明显高于对照组(15%vs9%,P=0.04),SS的疾病活动性对出生体重百分率有显著影响,1例先天性心脏传导阻滞胎儿。结论:SS妊娠患者早产发生率及低比重胎儿的比例明显高于健康对照组,抗SSA抗体与自然流产有关。

Objective:To investigate the effect of Sjogren’s syndrome on fetal and pregnancy outcomes in pregnant women.Methods:Forty-eight pregnant women with Sjogren’s syndrome were selected as study subjects,and 96 normal subjects matched with age and body mass index were selected as control group.According to whether the patients had regular treatment before pregnancy,they were divided into regular treatment group and irregular treatment group.The relationship between Sjogren’s syndrome and abnormal pregnancy was analyzed.Results:The rate of spontaneous abortion in Sjogren’s syndrome group was significantly earlier than that in the control group(38 weeks+3 days vs 39 weeks+2 days).The incidence of spontaneous abortion was much higher that of the Sjogren’s syndrome group(15%vs.9%,P=0.04).The activity of Sjogren’s syndrome had a significant effect on the percentage of birth weight.One case of congenital heart block fetus happened.Conclusion:The incidence of premature delivery and the proportion of low-specific foetus in Sjogren’s syndrome pregnancy are significantly higher than those in the healthy control group.Anti-Sjogren’s antibody is related to spontaneous abortion.