25-羟维生素D与糖尿病肾病的相关性研究进展

Advances in research on the relationship between 25-hydroxyvitamin D and diabetic nephropathy

糖尿病肾病是2型糖尿病(type 2 diabetes mellitus,T2DM)最常见并发症之一,为微血管损伤引起的肾功能损伤,其发生发展机制复杂,维生素D的缺乏与不足可能与糖尿病肾病的发生具有一定的相关性。维生素D作为钙磷调节药在临床上广泛应用,近年研究表明T2DM合并肾病患者存在严重的维生素D缺乏,具有活性的维生素D在T2DM发展、糖尿病肾病进展中发挥着保护作用,这种作用与经典钙磷调节模式不尽相同。

Diabetic nephropathy is one of the most common complications of type 2 diabetes mellitus(T2DM),which is one kind of the damage of renal function caused by microvascular damage,whose occurrence and development mechanism are complex.The deficiency and deficiency of vitamin D may be correlated with the occurrence of diabetic nephropathy.Vitamin D is widely used as calcium phosphate regulator in clinic.In recent years,studies have shown that patients with T2DM with nephropathy exist severe vitamin D deficiency.Having the activity of vitamin D plays a protective role in the development of T2DM and diabetic nephropathy progress.This effect is not the same as the classical calcium phosphate adjustment mode.This paper will make a brief discussion about the study correlation between the 25-hydroxy vitamin D levels and diabetic nephropathy.