盐酸氨基葡萄糖对骨关节炎作用机制的初步探讨

Study on the role of glucosamine hydrochloride in the pathogenesis of osteoarthritis

为了探索盐酸氨基葡萄糖对骨关节炎的作用机制 ,通过建立棉球肉芽肿、白陶土诱导的骨关节炎和佐剂性骨关节炎实验动物模型研究方式进行研究。结果显示 ,盐酸氨基葡萄糖每日经口给入 0 2 5～0 75g kgBW剂量可抑制肉芽组织增生、迟发性免疫反应和免疫性骨节炎 ;在 0 5～ 1 5g kgBW剂量能抑制血管渗出 ,组织水肿和细胞游离。

The role of glucosamine hydrochloride in the pathogene sis of osteoarthritis in animal models of sponge granuloma, Kaolin arthritiaand and adjuant arthritis was studied. The results showed that glucosamine hydrochl oride inhibited granulation, delayed immunoreactivity, immunological-reative arthrit is in daily doses of 0 25-0 75g/kg BW orally and vascular oozing, tissue swell ing and cell isolating in daily doses of 0 5-1 5 g/kg BW orally, indicating th at glucosamine hydrochloride might have a preventive and theraputic effect on os teoarthritis.