HPTH(1-34)及hPTHrP(1-34)的结构与功能的关系

The Relationship of the Structures and Functions of hPTH(1-34) and hPTHrP(1-34)

对各种结构研究及检测方法所得hPTH(1-34)及hPTHrP(1-34)的空间结构进行综合整理,探讨其结构与功能的关系及其应用意义。分别以N端,C端,连接区为着眼点,对hPTH(1-34)及hPTHrP(1-34)在溶液中的构象及其晶体结构进行综述,讨论了特定氨基酸对该多肽的激动剂活性以及受体结合活性的影响,并对这些影响在该多肽结构改造上的意义进行了展望 hPTH(1-34)及hPTHrP(1-34)是由负责生理活性的N端和负责受体结合的C端以及结构随环境而改变的连接区组成的。对hPTH(1-34)及hPTHrP(1-34)结构知识的深入了解必将对理论研究及临床实践产生重要意义。

To sum up and put in order the results of the spacial structures of hPTH( 1-34) and hPTHrP( 1-34) acquired from various structure researches and assays, and consult the relationship between the structures and functions and the practical significance. In light of N-termini, C-termini and the linker region, conformations in solution and crystal structures of hPTH(1-34) and hPTHrP(1-34) were reviewed according to the papers recently reported in the home and oversea journals, the effects of any definite amino acids on the agonist activity and receptor binding capacity were discussed, the significance of those effect on the peptide's structure modification was prospected. hPTH(1-34) and hPTHrP( 1-34) consist of N termini which are responsible for agonist activity, C termini which are responsible for receptor binding, and the linker regions whose conformations always change along with the environment. Great and far-reaching significance will be produced by comprehending the structure information of hPTH(1-34) and hPTHrP(1-34).