应用卡托普利联合倍他乐克治疗慢性心力衰竭的临床观察

Captopril-Betaloc combination in the treatmeat of congestive heart failure

目的 观察卡托普利和倍他乐克联合应用对慢性心力衰竭 (CHF)的远期疗效。方法 共选择CHF患者 98例 ,随机分为对照组和治疗组。对照组采用常规治疗 (即强心、利尿、扩血管 ) ,治疗组在此基础上加用卡托普利 (12 .5 - 75mg/d)和倍他乐克 (12 .5 - 5 0mg/d) ,在治疗前和观察期满 2年时分别对心功能 (NYHA)Ⅱ -Ⅲ级患者作 6分钟步行距离试验。结果 2年期间 ,对照组和治疗组因心力衰竭加重再住院率分别为 80 .4 3%和2 5 .0 0 % ,病死率分别为 13.0 %和 1.90 % (P <0 .0 5 ) ,与治疗前比较 ,治疗组心功能及 6分钟步行距离有明显改善(P <0 .0 0 1) ,而对照组无明显改善。

Objective To observe a long term effect of angiotension converting enzyine inhibition (ACE-I captopril) and β blocker (Betaloc).Methods To combine in the treatment of congestive (control group n=46) or a combine of captopril (12.5-75mg/d) and Betaloc (12.5-37.5mg/d) (n=52) in addition to the conventional treatment (combination group).Patients were observe for 2 years.The heart function and the distance for 6 minute walking test were assessed before and after the study.Results In the 2 years,the mortacity rate for the conventional and combination groups were 13.0% and 1.9% respectively (P<0.05).The heart function in the conventional treatment group had been changes.Furthermore the distance of 6 minute walking test was increased sudstantidy in comination group and no changed in the control group .Conclusion Combined with Betaloc can significantly improve the long term mortality and mortality in patients with congestive heart failure. [