药物基因组学与合理用药研究进展

Advances of the study on pharmacogenomics and reasonable use of drugs

目的介绍药物基因组学及其在临床制定治疗方案中的应用。方法根据有关文献 ,综合分析、归纳总结药物基因组学和临床药物基因组学的发展、研究内容及与个体化用药的关系。结果药物基因组学研究表明 ,基因多态性与药物作用多样性之间的关系非常密切。结论药物基因组学为安全、有效和合理用药提供了理论依据。

Objective To introduce pharmacogenomics and its applications to establishing clinical pharmacotherapeutic schemes.Methods Being based on the analysis of the related literature,the development and contents of pharmacogenomics and clinical pharmacogenomics and their relationship with individualized medication were summarized.Results Pharmacogenomic studies proved the relationship between the gene polymorphisms and the variety of drug effects.Conclusions Pharmacogenomics provides a theoretical basis for medication with safety,effectiveness and rationality.