摘要
Four hydroxamic acid derivaties were prepared by reaction of hydroxylamine hydrochloride with dimethylphthalate, dimethylisophthalate, dimethylterephthalate and dimethylsebacate respectively and characterized by IR and elemental analysis. The antibacterial activities to Escherichia coli and Staphylococcus aureus of phthaloyl, isophthaloyl, terephthaloyl and sebacoyl hydroxamic acids have been determined using paper disc method. The result indicates that their antibacterial activities to Escherichia coli are better than that to Staphylococcus aureus and among them the sebacoyl hydroxamic acid is the best one. No linear correlation was observed between the antibacterial activities and the concentration of the compounds, each has its optimum antibacterial concentration.
Four hydroxamic acid derivaties were prepared by reaction of hydroxylamine hydrochloride with dimethylphthalate, dimethylisophthalate, dimethylterephthalate and dimethylsebacate respectively and characterized by IR and elemental analysis. The antibacterial activities to Escherichia coli and Staphylococcus aureus of phthaloyl, isophthaloyl, terephthaloyl and sebacoyl hydroxamic acids have been determined using paper disc method. The result indicates that their antibacterial activities to Escherichia coli are better than that to Staphylococcus aureus and among them the sebacoyl hydroxamic acid is the best one. No linear correlation was observed between the antibacterial activities and the concentration of the compounds, each has its optimum antibacterial concentration.
出处
《应用化学》
CAS
CSCD
北大核心
2004年第1期87-89,共3页
Chinese Journal of Applied Chemistry
基金
天津市 2 1世纪青年基金 (0 0 3 70 0 711)
天津市自然科学基金 (0 0 3 60 1711)资助项目
关键词
苯二酰异羟肟酸
癸二酰异羟肟酸
大肠杆菌
金黄色葡萄球菌
抑菌活性
phthaloyl hydroxamic acid,sebacoyl hydroxamic acid, escherichia coli , staphylococcus aurous , antibacterial activities
