摘要
We determined and analysed the ApoE polymorphism of 30 sporadic Alzheimer’s disease (AD) pa- tients, 27 patients with multi-infarct dementia (MID) and 46 aged healthy subjects as control. The results showed that the frequency of ApoE E4/3 genetype in AD group was significantly higher than that in con- trol (P<0. 05). Among these three groups, ApoE 4 allele frequency in AD group was significantly higher than that in control (P<0. 01 ) and MID group (P<0. 05). Among the three ApoE alleles, the risk ratio of ApoE E4 allele in AD group was 4. 114(p<0. 01 ). There was statistically significant (P<0. 05) as the increasing of ApoE 4 gene dose in AD. It suggests that ApoE is related to AD of Chineses and it might be a genetics index of early diagnosis for AD.
