31例地高辛中毒血药浓度监测结果分析

Studies on serum concentration of digoxin toxicity in 31 patients

目的:分析地高辛血药浓度监测结果以了解中毒的发生与地高辛血浓度的相关性。方法:制定地高辛中毒的诊断标准,并采用荧光偏振免疫法测定血清地高辛浓度。结果:213例患者中,有31例发生中毒。中毒发生率14.5％。结论:地高辛中毒的发生与地高辛血浓度的高低有一定的相关性,并随地高辛血浓度的升高而增加。

objective: To understand the relationship between digoxin toxicity and serum digoxin concentration. Methods: The criterion for diagnosis of digoxm toxicity was established. The serum digoxin concentration was measured by fluorescence polarization immunoassay. Results: 31 of 213 patients receiving digoxin were intoxicated. The incidence of toxicity was 14.5% . Conclusion: The occurence of digoxin toxicity is close related to serum digoxin levels, and the risk of digoxin toxicity is increased with the increase of serum digoxin concentration.