摘要
目的 通过观察长期白酒灌胃对实验性大鼠纤溶、凝血因子、抗凝、内皮功能、血脂水平等方面的影响,研究饮酒与实验性大鼠血栓形成的关系及作用机制。方法 本实验以SD大鼠为实验动物,分为空白对照组,白酒高、中、低剂量组,白酒合并中药/高脂饲料组,乙醇对照组共7组。给大鼠白酒灌胃4个月时处死动物,取血检测。结果 长期白酒灌胃对大鼠t-PA、PAI、vWF影响不明显(P>0.05);高、中量大鼠PT、APTT、TT、AT一Ⅲ水平较空白对照组均有明显缩短(P<0.05)。结论 长期白酒灌胃对大鼠纤溶活性及内皮功能影响不明显,但可能会造成体内高凝血状态,增加血栓形成发生的危险。
Objective To research the relationship and the mechanics of drank and albino rat thrombosis through long - term observation on artificial gastro feeding.And also.to explore some index such as ino- dissolution system, blood coagulation factor, anti
- blood coagulation system, endothelium function, blood - fat level. Methods Albino rats were divided into 7 groups (blank contrast group, ethanol contrast group, high dose, medium dose and small dose alcoholic mass group, alcoholic mass at the meantime eat high fat feedstuff or Chinese drugs group) , they were killed after 4 month. Results There was no obvious impact to albino rats on t - PA,PAI, vWF ( P > 0.05) that long - term artificial gastro feeding alcoholic; High dose and medium dose alcoholic mass group albino rats' PT, APTT, TT time was shorter than that of blank control group (P < 0.05) .But AT- III level was higher than it ( P
< 0.05) . Conclusions The impact to ino - dissolution system and endothelium function is not obvious which long - term artificial alcoholic mass gastro feeding to albino rat. But it maybe lead to high blood coagulation state, which can increase occurrence dangerous-ness of thrombosis.
出处
《中国预防医学杂志》
CAS
2003年第4期249-252,共4页
Chinese Preventive Medicine
基金
国家自然科学基金(项目 39970643)
