广西围产儿出生缺陷危险因素的干预模式研究

AN INTERVENTION MODEL STUDY ON RISK FACTORS FOR PERINATAL BIRTH DEFECTS IN GUANGXI

目的 :探讨广西围产儿出生缺陷发生与环境危险因素的关系及规划相应的出生缺陷干预措施。方法 :采用 COX回归模型对广西 2 0 0 0年出生的围产儿 10 75例 (包括出生缺陷儿 317例和正常对照儿 75 8例 )进行干预模式拟合。结果 :COX回归模型多因素分析结果显示 :母亲孕期暴露于农药、激素类药、妊娠合并症、镇静药、中成药、母亲患地中海贫血、父亲接触化学制剂、母亲孕期体力劳动过重和产次大于 2次且孕期营养不良等 9个因子具有统计学意义 ,其相对危险度 RR分别为 6 .836、3.2 16、3.16 3、2 .0 5 8、1.96 5、1.818、1.80 3、1.5 6 8和 1.30 3。结论 :今后在广西进行出生缺陷干预时可从优生健康教育和对高危孕妇孕期监测等方面入手。

Objective:To explore the relation between the environmental risk factors and perinatal birth defects in Guangxi so as to take measures to intervene the occurrence of perinatal birth defects.Methods:Statistical analysis was done by modeling the data through COX regression model,which consisted of 1 075 perinatal born in Guangxi in the year 2000,317 cases with birth defects and 758 controls without birth defects.Result:COX model multivariate analysis indicated that exposed to risk factors during pregnancy were statistically significant: maternal pesticide (RR=6.836), maternal hormone (RR=3.216), maternal pregnancy complications (RR=3.163), maternal sedatives (RR=2.058), maternal traditional Chinese medicine (RR1.965),maternal thalassemia(RR=1.818), paternal chemicals (RR=1.803), maternal overburdened physical labor during pregnancy (RR=1.568),maternal parity more than twice & malnutrition in gestation period (RR=1.303).Conclusion:So we could succeed in the movement of health education for eugenics and monitoring the high risk pregnancy women to intervene the occurrence of birth defects.